3/15/2024 0 Comments Ibm spss 16.0 free downloadHowever, some studies reported that MB significantly altered diastolic flow and reduced coronary flow in patients with HCM, which could be responsible for myocardial ischemia and further affect myocardial fibrosis. Previous studies have shown that MB does not affect the long-term prognosis of HCM. MB is common in patients with hypertrophic cardiomyopathy, with a prevalence of 11–37%. Myocardial bridging (MB), a congenital anomaly, is characterized as a segment of the epicardial coronary artery that traverses through the myocardium, resulting in systolic compression of the tunneled artery. Left ventricular output tract obstruction (LVOTO) with high left ventricular wall stress could worsen ischemia. Myocardial fibrosis in HCM could be partly attributable to myocardial ischemia resulting from a mismatch between myocardial oxygen supply and demand. Myocardial fibrosis is one of the major histologic hallmarks of hypertrophic cardiomyopathy (HCM), and extensive fibrosis is an independent risk factor for poor prognosis. Identification of patients with severe MB and providing comprehensive management might help improve the prognosis of patients with HCM. Concomitant myotomy or coronary artery bypass grafting might provide excellent survival similar to that of patients without MB. MB with severe systolic compression was significantly associated with a high extent of fibrosis in patients with obstructive HCM. Kaplan–Meier analysis did not identify differences in all-cause death (log-rank p = 0.63) or cardiovascular death (log-rank p = 0.72) between patients undergoing MB-related surgery and those without MB. During a median follow-up of 28 (IQR: 15–52) months, 15 patients died. The LGE fraction of basal and mid anteroseptal segments in patients with severe MB (compression ratio ≥ 80%) was significantly greater than that in patients with mild to moderate MB (compression ratio < 80%). Multivariable linear regression analysis revealed that the degree of systolic compression was an independent risk factor for LGE ( β = 0.292, p = 0.007). The global extent of late gadolinium enhancement (LGE) was correlated with the degree of systolic compression ( r = 0.33, p = 0.003). MB occurred mostly in the left anterior descending artery (73/76). Resultsįinally, 492 patients were included in this study, with an average age of 45.7 years. Patients with obstructive HCM who underwent septal myectomy and preoperative cardiac magnetic resonance (CMR) were screened from 2011 to 2018. In this cohort study, retrospective data were collected from a high-volume HCM center. This study was designed to evaluate the relationship between MB and myocardial fibrosis in patients with obstructive HCM. There are sparse data on the impact of MB on myocardial fibrosis in HCM. Myocardial bridging (MB) is common in patients with hypertrophic cardiomyopathy (HCM).
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